177Lu-DOTATATE Molecular Radiotherapy for Childhood Neuroblastoma
نویسندگان
چکیده
منابع مشابه
Quantitative accuracy of 177Lu SPECT imaging for molecular radiotherapy
The purpose of this study is to investigate the optimal reference geometry for gamma camera calibration. Yet another question of interest was to assess the influence of the number of 3D Ordered Subsets Expectation Maximization (3D-OSEM) updates on activity quantification for SPECT imaging with 177Lu. The accuracy of 177Lu activity quantification was assessed both in small and in large objects. ...
متن کاملTargeted radiotherapy for neuroblastoma.
Background Biologically targeted radiotherapy is an established treatment for thyrotoxicosis and thyroid cancer. The principle is to take advantage of the ability of the thyroid and, to a lesser degree, diVerentiated thyroid carcinoma to concentrate and retain iodide. In this situation the radionuclide (I) in ionic form is a natural substrate for targeting thyroid tissue, thus acting both as th...
متن کاملMolecular Markers in Neuroblastoma
Neuroblastoma, one of the common malignant childhood tumors, arises from neuroblast cells derived from theneural crest and destined for the adrenal medulla and the sympathetic nervous system and shows remarkable biologicalheterogeneity, resulting in favorable or unfavorable outcomes. Some tumors make rapid progress with a fataloutcome. In other instances, the tumors regress spontaneously in inf...
متن کاملSPECT image segmentation for estimation of tumour volume and activity concentration in 177Lu-DOTATATE radionuclide therapy
BACKGROUND Dosimetry in radionuclide therapy has the potential to allow for a treatment tailored to the individual patient. One therapeutic radiopharmaceutical where patient-specific dosimetry is feasible is 177Lu-DOTATATE, used for the treatment of neuroendocrine tumours. The emission of gamma photons by 177Lu allows for imaging with SPECT (single photon emission computed tomography). One impo...
متن کاملAccuracy and precision assessment for activity quantification in individualized dosimetry of 177Lu-DOTATATE therapy
BACKGROUND In order to obtain a reliable 177Lu-DOTATATE therapy dosimetry, it is crucial to acquire accurate and precise activity measurements with the radionuclide calibrator, the SPECT/CT camera, and the NaI(Tl) well counter. The aim of this study was to determine, in a clinical context, the accuracy and the precision of their activity quantification over a range of activities and time. Ninet...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2011
ISSN: 0161-5505,2159-662X
DOI: 10.2967/jnumed.110.085100